IJSEA Archive (Volume 4, Issue 2)
International Journal of Science and Engineering Applications (IJSEA) (Volume 4, Issue 2 March-April 2015)
Synthesis of novel 5-{[2-(4-fluorobenzyl)-6-arylimidazo[2,1-b] [1,3,4]thiadiazol-5-yl]methylene}thiazolidine-2,4-diones as potent Antidiabetic agents
Keywords: Imidazothiadiazoles, Thiazolidinediones, Hypoglycemic activity, Hypolipidemic activity, Antidiabetic agents.
A series of novel 5-[2-(4-fluorobenzyl)-6-aryl-imidazo[2,1-b][1,3,4]thiadiazol-5-ylmethylene] thiazolidine-2,4-dione derivatives (4a-d) were synthesized. These final compounds (4a-d) were synthesized by Knoevenagel condensation of 2-(4-fluorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (3a-d) with thiazolidine-2,4-dione. All the newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activity in male Wister rats. The Structures of all the newly synthesized compounds were established by analytical and spectral data.
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@article{Naveen04021001,
title = " Synthesis of novel 5-{[2-(4-fluorobenzyl)-6-arylimidazo[2,1-b] [1,3,4]thiadiazol-5-yl]methylene}thiazolidine-2,4-diones as potent Antidiabetic agents ",
journal = "International Journal of Science and Engineering Applications (IJSEA)",
volume = "4",
number = "2",
pages = "24 - 29",
year = "2015",
author = " Naveen P.Badiger ",
}