South East Asia including Myanmar is situated in secondary seismic belt. Therefore, it is necessary to pay special attention of the effect of earthquake in designing the high-rise building. Shear walls are very common in high rise reinforced concrete building. In this study, comparative analysis of high-rise reinforced concrete irregular building with shear walls are present. The frame type of proposed building is used the special RC moment resisting frame. It belongs to seismic zone 4. This is why, seismic forces are essentially considered in the analysis of this building and shear walls are also provided to resist seismic forces. Structural members are designed according to ACI Code 318-02. The structure is analysed by using ETABS v 9.7.1 software. Load consideration is based on UBC-97. All necessary load combinations are considered in shear walls analysis and frame analysis. In addition wind load, seismic load is considered as external lateral load in the dynamic analysis. In dynamic analysis; Response Spectrum method is used. In this project, study of 14 storey building is presented with some investigation which is analyzed by changing various location of shear wall for determining parameters like storey drift, storey shear and storey moment .