Research on the cultivation plan of college students' autonomous learning ability based on blended teaching mode is the main focus of this paper. Self-directed learning is actually metacognitive monitoring of learning It is a process in which students proactively adjust their learning strategies and efforts according to their own learning ability and the requirements of the learning task. The process of Self-directed learning requires individuals to have conscious awareness and response to the questions of why, whether, what, and how they learn. and how to learn. In the process of the teacher-student interaction, learning feedback and online mutual evaluation are the main ways for teachers and students to communicate. We give the new suggestions of improving the performance.