Practice and further thinking of modern flipped classroom teaching mode in university students' career education is studied in this paper. Career education guidance in colleges and universities must conform to the development trend of new media, deeply analyze the advantages and disadvantages of new media for college students' employment and entrepreneurship, and at the same time carry out a comprehensive integration of the latest framework. The flipped classroom starts after the class. Students learn by actively searching for information or watching videos. Teachers can make some online courses and also record some videos to let students learn some knowledge actively. Accordingly, the proper combinations are considered.