Analysis of drug resistance characteristics of Acinetobacter baumannii in burn wound infection is studied in this paper. The resistance rates of Acinetobacter baumannii to amikacin, ampicillin-sulbactam, and cefoperazone-sulbactam were low, and the resistance rates to these drugs were not significantly correlated with the intensity of their use. The study of MDR Acinetobacter baumannii bloodstream infection suggests that admission to ICU and application of more than 2 types of antibiotics are independent risk factors for MDR Acinetobacter baumannii bloodstream infection. This paper studies the background and the related applications.