Artificial neural network (ANN) is one of the practical methods for prediction in various sciences. In this study, which was carried out on Glass and Crystal Factory in Isfahan, the amount of silica purification used in industry has been investigated according to its analyses. In this discussion, according to the artificial neural network algorithm back propagation neural network (BPNN), the amount of silica (SiO2) was predicted according to rock main oxides in chemical analysis. These studies can be used as a criterion for estimating the purity for use in the factory due to the high accuracy obtained.