In order to adapt to the development of the times, many colleges and universities adopt the school enterprise cooperation mode to cultivate engineering applied talents. In order to improve the training quality of engineering application-oriented talents, first of all, the paper analyzes the problems existing in the current school enterprise cooperation education model in colleges and universities in China; Secondly, it discusses the necessity of the educational mode of school-enterprise cooperation in training engineering applied talents; This paper mainly discusses the basic contents, existing problems and solutions of the cooperation between schools and enterprises in training engineering applied talents. The "2+1" semester system is put forward in order to become a new model of school-enterprise cooperative training; It puts forward the scientific research orientation of "standing on top of the earth" to support and encourage teachers to improve their practical ability.