Guided by professional competence, improving the teaching mode of tourism management specialty in application-oriented undergraduate colleges, promoting the construction of "double-qualified" teacher team, and promoting the combination of work and learning, school-enterprise cooperation are the inevitable trend of the teaching reform of tourism management specialty in application-oriented undergraduate colleges. In this regard, this paper focuses on the analysis of the characteristics of the cultivation of professional competence talents in tourism management, and expounds the necessity of improving the practical ability of tourism management students in application-oriented undergraduate colleges and universities with the guidance of professional competence. The innovation and entrepreneurship and practical education abilities of innovation and entrepreneurship teachers in application-oriented undergraduate colleges and universities need to be strengthened. Specifically, the innovation and entrepreneurship education teaching methods, teaching content system, innovation and entrepreneurship opportunity identification Practical guidance and the ability to integrate expertise and innovation are the key points that should be improved or improved. Based on this, the paper puts forward the main countermeasures to improve the innovation and entrepreneurship competence of teachers in application-oriented undergraduate colleges.