School-enterprise cooperation is not only one of the prominent features of modern vocational education, but also helps to strengthen the cooperation between vocational colleges and enterprises, and the combination of teaching and production. It is an important way to realize the development of modern vocational education and build a high-skilled personnel training system. From the perspective of the significance of school-enterprise cooperation in the process of cultivating high-skilled talents, the key factors of the cultivation system of high-skilled talents based on school-enterprise cooperation, the mechanism of "government leadership, industry guidance, and enterprise participation" should be played to promote the deep integration of vocational education with industrial and regional economic development, improve the quality of the cultivation of skilled talents in high-end equipment manufacturing industry, and improve the innovation of the cultivation mode of high-end equipment talents.