Due to the acceleration of the aging process of our country's population, and with the development of the economy, people have formed many bad eating and living habits, and the cerebrovascular disease has a younger trend, and the morbidity and mortality are increasing year by year. Therefore, further research on cerebrovascular diseases is one of the most important topics in medicine. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is produced by Escherichia coli implanted with human granulocyte-colony-stimulating factor (G-CSF) gene through recombinant DNA technology and has the same biological activity as natural G-CSF and amino acid sequence, is a protein consisting of 175 amino acids. After cerebral ischemia, neuron apoptosis is caused by a series of biochemical cascade reactions, resulting in dysfunction of corresponding areas of the brain and a series of ischemic symptoms. Therefore, it is particularly important to find effective drugs to inhibit the apoptosis of neurons after cerebral ischemia to improve the prognosis of ischemic stroke.