As the main force of ideological and political education in university courses, professional course teachers play a crucial role in the implementation of professional course ideological and political education. By using analytical methods to systematically analyze the advantages, disadvantages, opportunities, and threats of ideological and political education for professional course teachers in universities, it is found that teaching cognition, knowledge reserves, teaching methods, and teaching mechanisms affect the effectiveness of ideological and political education for professional course teachers. As the theoretical teaching guide for innovation and entrepreneurship education, the research ability of ideological and political course teachers is not only closely related to the development of their professional level, but also has an impact on the effectiveness of ideological and political education and the quality of innovation and entrepreneurship education. Therefore, exploring the related issues of improving the research ability of ideological and political course teachers has certain research value for promoting innovation and entrepreneurship education.