Application of the computer multimedia-assisted online virtual interactive platform in smart college education is studied in the paper. The model we designed is based on the client-side virtual container technology. The so-called virtual container actually completely virtualizes the terminal and builds a virtual container pool on which the operating system is then deployed. In the designed model, the virtual performance is then considered. NSX network virtualization is divided into the NSX-V architecture in the vSphere environment and the NSX-MH architecture in the multi-virtual environment . Furthermore, the smart model is integrated to construct the efficient computer multimedia-assisted online virtual interactive platform in smart college education. The testing has shown the performance.