Due to the complexity and dispersion of environmental issues, directly defining their property rights cannot truly solve environmental quality problems. This article proposes an indirect solution to the industrialization of environmental resources and elaborates on the specific content and external guarantee policies of the industrialization of environmental resources. This article uses a game model and its extended analysis to indicate that the source of resource-based industrial clusters is the result of the comprehensive effect of regional effects and agglomeration effects. The formation of resource-based industrial clusters is influenced by transportation costs, final product demand functions, regional effects, agglomeration effects, and the gap in agglomeration effects between two regions.