This article presents the effects of opening on shear wall for thirteen-storeyed U shape RC building, which is situated in seismic zone (4).This structure is setback building. The elevations and plans of this structure are irregularity in shape. Special moment resisting frame is considered in this structure. This structure is analyzed under dead load, live load, wind load, earthquake load and all necessary load combinations are considered by using UBC 97. The modeling and analyzing of each member is done by ETABS 16.0.3. All of structural members are designed by ACI 318-14. Response spectrum analysis is used for dynamic analysis. First, the proposed building is analysed and design by using ETABS software. The shear wall of proposed building is opened with various percentage of opening and three different patterns. There are three types of patterns opening patterns (center 0pening,staggered opening and two vertical opening).The size of openings of shear wall are 13.6%, 25% and 35% of shear wall area. This article include comparative study of storey displacement, storey shear and storey moment under seismic force due to three configurations of openings in shear walls. According to the comparisons of these results, the maximum structural response is occurred at the structure having shear wall is with two vertical opening.