In this research, bottle filling and capping processes are performed simultaneously in the pharmaceutical factory by using the PC based human machine interface (HMI) control system. In the traditional method of bottle filling process, the bottles are placed onto a conveyor and only one bottle is filled at a time. So, this method is time consuming and expensive as wide working place and many human labors is required. In this research, the proposed design can solve this problem without any complex control by using the HMI automation control system. The monitoring and running conditions in the packaging system are shown on the monitor of computer by using the composed of Visual Basic.Net and Mikro C. It also includes the volume of medical powder is limited by changing the size of filling funnel which is set up of shutter at the top and bottom of funnel. The entire system is more flexible and time saving. A prototype is implemented by using the DC motor, sensing devices; limit switches, peripheral interface controller (PIC) device and serial port communication. These control systems is very flexible, cost effective, space efficient and reduce complexity. PC based HMI control is used for monitoring the process.